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Invitrogen™ B7-H3 (CD276) Monoclonal Antibody (M045)
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Catalog No. PIMA547649
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PIMA547649 100 μL
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Catalog No. PIMA547649 Supplier Invitrogen™ Supplier No. MA547649
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Description

Mouse Monoclonal Antibody

Clone M045 mouse monoclonal antibody detects a 100-120 kDa* protein on SDS-PAGE Native or denatured immunoblots of human LNCaP, MCF-7, NCI-H28, A431, and MDA-MB-231 carcinomas. The antibody detects B7-H3 in membranes and cytoplasm in MCF7 cell after immunocytochemical labeling. The antibody works for western blot, immunoprecipitation, immunocytochemistry, and ELISA capture.

CD276 is a member of the B7 family of co-stimulatory molecules also known as B7-H3. CD276 is a type I transmembrane protein that induces the proliferation of CD4+ and CD8+ T cells, enhances the generation of cytotoxic T cells and selectively stimulates the production of interferon gamma. Expression of CD276 can be induced on dendritic cells and monocytes by inflammatory cytokines, and is also widely expressed in peripheral tissues including the heart, kidney, testis and colon. In humans, CD276 exists as two isoforms which result from gene duplication and differential splicing. CD276 is reported to have therapeutic potential for the regulation of cell-mediated immune responses to cancer, particularly in conjunction with anti-angiogenic therapy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen B7-H3 (CD276)
Applications ELISA, Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone M045
Concentration 0.25 mg/mL
Conjugate Unconjugated
Formulation PBS with 1 mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene CD276
Gene Accession No. Q5ZPR3
Gene Alias 4Ig-B7-H3; 6030411F23Rik; AU016588; B7 homolog 3; B7h3; B7-H3; B7RP-2; CD276; CD276 antigen; CD276 molecule; CD276 molecule tv1; costimulatory molecule; PSEC0249; sB7 H3; sB7H3; sCD276; soluble B7 H3; soluble B7H3; soluble CD276; UNQ309/PRO352
Gene Symbols CD276
Host Species Mouse
Immunogen Clone (M045) was generated from a recombinant protein that included the extracellular region of human B7-H3 protein.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80381
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG1
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