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Invitrogen™ B7-H6 Monoclonal Antibody (JAM1EW), PE, eBioscience™, Invitrogen™
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Catalog No. 12652642
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12-652-641 25 Tests
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Catalog No. 12-652-642 Supplier Invitrogen™ Supplier No. 12652642
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Description

Mouse Monoclonal Antibody

Description: This JAM1EW monoclonal antibody recognizes human B7-H6 (NCR3LG1) protein on the surface of cells. It recognizes protein on live but not on paraformaldehyde-fixed cells. The JAM1EW clone is specific to B7-H6. When tested in flow cytometry against cells transfected with either B7-H4, B7-H5, B7-H6, or B7-H7, clone JAM1EW only stains positively on B7-H6 transfected cells. Applications Reported: This JAM1EW antibody has been reported for use in flow cytometric analysis. Applications Tested: This JAM1EW antibody has been pre-diluted and tested by flow cytometric analysis of HeLa and HL-60 cell line. This may be used at 5 μL (0.25 μg) per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser

B7-H6 (NCR3LG1) is a transmembrane endogenous ligand expressed on the surfaces of tumor cells. B7-H6 binds with NKp30 present on NK cells. Binding of B7-H6 to NKp30 causes the ligation of NKp30 subsequently inducing NK cell activation and target cell cytolysis. B7-H6 is not constitutively expressed on normal tissue. Whether it can be expressed endogenously under certain conditions is under investigation. B7-H6 has been detected on circulating pro-inflammatory CD14(+)CD16(+) monocytes in some patients with sepsis.
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Specifications

Antigen B7-H6
Applications Flow Cytometry
Classification Monoclonal
Clone JAM1EW
Concentration 5 μL/Test
Conjugate PE
Formulation PBS with BSA and 0.09% sodium azide; pH 7.2
Gene NCR3LG1
Gene Accession No. Q68D85
Gene Alias B7 homolog 6; B7H6; B7-H6; DKFZp686I21167; DKFZp686O24166; natural cytotoxicity triggering receptor 3 ligand 1; natural killer cell cytotoxicity receptor 3 ligand 1; NCR3LG1; putative Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167
Gene Symbols NCR3LG1
Host Species Mouse
Immunogen B7-H6 recombinant protein.
Purification Method Affinity chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 374383
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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