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Invitrogen™ BacMam Histone H3 Reagent

Catalog No. A14154
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A14154 100 mL
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Catalog No. A14154 Supplier Invitrogen™ Supplier No. A14154

Description

The BacMam Histone H3 Reagent provides a convenient genetic delivery tool for the expression of GFP-Histone H3 fusion protein in your cell background of interest.

The BacMam Histone H3 Reagent provides a convenient genetic delivery tool for the expression of GFP-Histone H3 fusion protein in your cell background of interest. The GFP fusion enables sensitive detection of post-translational modifications using LanthaScreen™ TR-FRET Cellular Assay technology.

The BacMam Histone H3 Reagent Lets You:

  • Use your cell background of choice with the portability of BacMam
  • Conserve precious cell samples with the miniaturizable homogenous assay format
  • Identify more relevant inhibitors since the methyl transferases and demethylases are in their natural protein complexes
  • Improve data quality with the advantages of TR-FRET

Get More Physiologically Relevant Results

The BacMam Histone H3 allows the investigation of post-translational modifications of histone H3 in your choice of cellular backgrounds, including primary cells. This enables screening for potential inhibitors of histone-modifying enzymes such as kinases, acetylases, deacetylases, methyl transferases, and demethylases in their natural complexes in a physiologically relevant cell type.

BacMam and LanthaScreen™ Convenience Saves Sample and Time

When used with a LanthaScreen™ Tb-anti-Histone H3 antibody against a specific modification, assays can be run in a fully homogenous, addition-only format without any of the washing, lysate transfer, or separation procedures required for traditional methods such as Western blotting and ELISA. By using the same BacMam reagent for GFP-Histone H3, a variety of histone H3 modifications (Ph, Me, Ac) can be monitored just by exchanging the Terbium (Tb) labeled antibody. In addition, the application of the LanthaScreen™ technology includes all of the advantages of TR-FRET detection, including reduced data noise, less interference from fluorescent compounds, and high sensitivity, allowing the use of fewer cells.

TRUSTED_SUSTAINABILITY

Specifications

Content And Storage Store the BacMam Histone H3 Reagent at 4°C
Delivery Type Baculovirus (BacMam System)
Quantity 100 mL
Shipping Condition Wet Ice

For Research Use Only. Not for use in diagnostic procedures.

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