BARD1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A300263A

Catalog No. 50-155-7230

Description

The recommended shelf life for this product is 1 year from date of receipt.

This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and domit protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer.

Specifications

• Antigen: BARD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BARD1
• Gene Alias: BARD-1, BRCA1 associated RING domain 1 isoform alfa, BRCA1 associated RING domain 1 isoform beta, BRCA1 associated RING domain 1 isoform delta, BRCA1 associated RING domain 1 isoform epsilon, BRCA1 associated RING domain 1 isoform eta, BRCA1 associated RING dom
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 580
• Content And Storage: 4° C
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot
• Concentration: 1 mg/ml
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene Accession No.: Q99728
• Gene Symbols: BARD1
• Immunogen: Between 250 and 300
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG