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  5. Tocris Bioscience™ BAY 598

Tocris Bioscience™ BAY 598

Catalog No. p-7161602
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective SMYD2 inhibitor

BAY 598 is a potent and selective competitive inhibitor of SMYD2 lysine methyltransferase (IC50 values are 27 and 58 nM for biochemical and cellular activity assays, respectively), which displays >100-fold selectivity for SMYD2 over a panel of 32 other methyltransferases including SMYD3, SUV420H1, and SUV420H2. BAY 598 enhances apoptotic responses to doxorubicin (Cat. No. 2252) in cancer cell lines, and decreases p53K370me levels in HEK293 cells. It also reduces methylation in tumor cells in a mouse xenograft model.

To request the negative control for BAY 598, please fill out the BAY 369 request form on the SGC website.

Specifications

Chemical Name or Material N-[(4 S)-1-[(Cyanoamino)[[3-(difluoromethoxy)phenyl]imino]methyl]-3-(3,4-dichlorophenyl)-4,5-dihydro-1 H-pyrazol-4-yl]-N-ethyl-2-hydroxyacetamide
CAS 1906919-67-2
Quantity 5 mg
Target Additional Lysine Methyltransferase Compounds
Molecular Formula C22H20Cl2F2N6O3
Formula Weight 525.34
Purity 98%
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