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Invitrogen™ Bcl-2 Monoclonal Antibody (Bcl2/100), FITC
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Catalog No. 501137097
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50-113-7097 100 Tests
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Catalog No. 50-113-7097 Supplier Invitrogen™ Supplier No. A15764
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Description

Mouse Monoclonal Antibody

This antibody recognizes Bcl2, a 26 kDa intracellular protooncogen with anti-apoptotic effect, expressed in outer mitochondrial membrane, endoplasmic reticulum and nuclear envelope.

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.
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Specifications

Antigen Bcl-2
Applications Flow Cytometry
Classification Monoclonal
Clone Bcl2/100
Conjugate FITC
Formulation PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Bcl2
Gene Accession No. P10415
Gene Alias apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50
Gene Symbols Bcl2
Host Species Mouse
Immunogen Synthetic peptide corresponding to the amino acids 41-54 of human Bcl2.
Purification Method Size-exclusion chromatography
Quantity 100 Tests
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 596
Target Species Human
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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