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Invitrogen™ Bcl-xL Monoclonal Antibody (7B2.5), PE
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Catalog No. PIMA528638
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PIMA528638 1 mL
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Catalog No. PIMA528638 Supplier Invitrogen™ Supplier No. MA528638
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Description

Mouse Monoclonal Antibody

Bcl-xL Monoclonal Antibody for Flow

BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bcl-xL
Applications Flow Cytometry
Classification Monoclonal
Clone 7B2.5
Concentration 0.1 mg/mL
Conjugate PE
Formulation PBS with proprietary stabilizer and <0.1% sodium azide; pH 7.5
Gene BCL2L1
Gene Accession No. P53563, Q07817, Q64373
Gene Alias anti-apoptosis regulatory protein; apoptosis regulator Bcl-X; B cell lymphoma 2 like; B cell lymphoma like X; B-cell leukemia/lymphoma x; Bcl(X)L; BCL2 like 1; Bcl2l; BCL2L1; bcl2-L-1; BCL2-like 1; Bcl-2-like protein 1; BCLX; bcl-x; BCLXL; Bcl-XL; BCL-XL/S; BCLXS; bcl-xS; Blc2l; DKFZp781P2092; EGK_02534; OTTHUMP00000030550; OTTHUMP00000030552; OTTHUMP00000030555; OTTHUMP00000030556; OTTHUMP00000030557; PPP1R52; protein phosphatase 1, regulatory subunit 52; RP5-857M17.3
Gene Symbols BCL2L1
Host Species Mouse
Immunogen Recombinant human Bcl-xS.
Purification Method Purified
Quantity 1 mL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12048, 24888, 598, 713035
Target Species Human, Mouse, Rhesus Macaque, Rat
Content And Storage 4°C, store in dark, DO NOT FREEZE!
Product Type Antibody
Form Liquid
Isotype IgG3 κ
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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