BCL2L11 Monoclonal Antibody (OTI2H5), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA812441

Catalog No. 50-168-4552

Description

BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Specifications

• Antigen: BCL2L11
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O43521
• Gene Symbols: BCL2L11
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-198 of human BCL2L11 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2H5
• Conjugate: Unconjugated
• Gene: BCL2L11
• Gene Alias: BAM, BIM, BOD
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10018
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid