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Invitrogen™ BDNF Polyclonal Antibody

Chicken Polyclonal Antibody

Supplier:  Invitrogen™ PA19522

Catalog No. 01-674-405


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Description

Description

PA1-9522 detects BDNF in human and mouse samples. PA1-9522 has been successfully used in ELISA procedures. PA1-9522 immunogen is two peptides from human BDNF that were mixed.

BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. BDNF is synthesized as pre-proBDNF, followed by cleavage to proBDNF. Although further processing generates the mature, 14 kDa protein, pro-BDNF is biologically active and is secreted in synaptic vesicles along with the mature form. BDNF is widely expressed in the central nervous system and acts in an autocrine and paracrine manner on several classes of neurons. Signaling occurs mainly through the tyrosine kinase receptor TrkB, although binding to the lower-affinity receptor, p75-NTR, has also been demonstrated. BDNF promotes neuronal survival and differentiation and has been shown to play a critical role in memory formation and synaptic regulation. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients, and may also play a role in the regulation of stress response and in the biology of mood disorders.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

BDNF
Polyclonal
Unconjugated
BDNF
abrineurin; ANON2; anorexia BDNF; Bdnf; BDNF precursor form; bdnf protein; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; BULN2; H-BDNF; neurotrophin; ProBDNF
Chicken
IgY fraction
RUO
12064, 627
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
ELISA
1 mg/mL
PBS with 0.02% sodium azide
P21237, P23560
BDNF
Two peptides from human BDNF that were mixed.
500 μg
Primary
Human, Mouse
Antibody
IgY
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