Bestatin hydrochloride, 98%, Thermo Scientific Chemicals

Description

Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Bestatin is an inhibitor of amino peptidases and a potent, irreversible inhibitor of LTA4 hydrolase. It inhibits the amino peptidase activity of LTA4 hydrolase with a Ki value of 201 nM. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation. It does not inhibit carboxypeptidases.

Solubility
Soluble in water (4 mg/ml, warm), DMSO (>25 mg/ml), methanol, acetic acid, dimethyl formamide, and 100% ethanol.

Notes
Store in cool, dry place in a tightly sealed container. Store away from oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 65391-42-6
• Molecular Formula: C16H25ClN2O4
• Molecular Weight (g/mol): 344.836
• MDL Number: MFCD00058004
• InChI Key: XGDFITZJGKUSDK-UDYGKFQRSA-N
• Synonym: bestatin hydrochloride, n-2s,3r-3-amino-2-hydroxy-4-phenylbutyryl-l-leucine hydrochloride, ubenimex hydrochloride, bestatin hcl, bestatin monohydrochloride, c16h24n2o4.hcl, bestatin hydrochloride hplc, bestatin, 2s,3r-3-amino-2-hydroxy-4-phenylbutanoyl-l-leucine hydrochloride
• PubChem CID: 11957481
• IUPAC Name: (2S)-2-[[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]amino]-4-methylpentanoic acid;hydrochloride
• SMILES: CC(C)CC(C(=O)O)NC(=O)C(C(CC1=CC=CC=C1)N)O.Cl

• Melting Point: 216°C to 218°C
• Color: White
• Quantity: 5 mg
• Beilstein: 4628066
• Solubility Information: Soluble in water (4mg/ml,warm),DMSO (>25mg/ml),methanol,acetic acid,dimethyl formamide,and 100% ethanol.
• Formula Weight: 344.87
• Percent Purity: 98%
• Physical Form: Powder
• Chemical Name or Material: Bestatin hydrochloride

Safety and Handling

TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only