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Beta-2-microglobulin Mouse anti-Human, Clone: 1C3B7, Proteintech
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Catalog No. 501736640 Shop All Proteintech Group Inc Products
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50-173-6640 150 μL
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Catalog No. 50-173-6640 Supplier Proteintech Group Inc Supplier No. 662071IG150UL
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Description

Mouse Monoclonal Antibody

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predomitly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

Specifications

Antigen Beta-2-microglobulin
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 1C3B7
Concentration 1.46 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene B2M
Gene Accession No. P61769
Gene Alias B2M, Beta-2-microglobulin, HDCMA22P
Gene Symbols B2M
Host Species Mouse
Immunogen Peptide
Purification Method Protein A
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 567
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG2b
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