Invitrogen™ beta Amyloid (1-42) Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 44344

Catalog No. 44-344

Description

Reacts with human Abeta42. No significant cross-reactivity to Abeta40 has been observed. Previous lots have shown no cross reactivity to Abeta43. Cross-reactivity against Abeta42 from mouse, rat, pig, cow, sheep, dog, rabbit, frog and polar bear (100% homology) is expected but has not been tested. The antibody has been used in ELISA. Previous lots of this antibody have been used in dot blots, RIA, and other related assays.

Beta amyloid is a 40-43 amino acid peptide cleaved from amyloid precursor protein by a protease, gamma-secretase. Beta Amyloid (1-40) (Amyloid beta 40 or Abeta 40) together with beta Amyloid (1-42) (Amyloid beta 42 or Abeta 42) are two major C-terminal variants of the amyloid beta protein, constituting the majority of amyloid beta proteins. Both the Amyloid beta 40 and Amyloid beta 42 alloforms are major components of the extracellular plaques found in Alzheimer's disease brain tissue.

Specifications

• Antigen: beta Amyloid (1-42)
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: APP
• Gene Alias: A beta 1 42; A ß 1 42; A4; AAA; AB42; Abeta; Abeta40; Abeta42; ABPP; AD1; Adap; AG; AICD-50; AICD-57; AICD-59; AID(50); AID(57); AID(59); Alpha-CTF; Alpha-secretase C-terminal fragment; Alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; Amyloid; amyloid A4; Amyloid b; Amyloid beta; amyloid beta (A4) precursor protein; Amyloid beta 1 42; amyloid beta A4 protein; amyloid beta precursor protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; Amyloid ß; Amyloid-beta A4 protein; Amyloid-beta precursor protein; Amyloid-beta protein 40; Amyloid-beta protein 42; Amyloidogenic glycoprotein; APP; APP-C57; APP-C59; APP-C99; APPI; appican; Aß 1 42; B APP42; BAPP42; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); beta-amyloid precursor protein; betaApp; Beta-APP40; BetaAPP42; Beta-APP42; Beta-CTF; Beta-secretase C-terminal fragment; C31; C80; C83; C99; Cerebral vascular amyloid peptide; CTFgamma; Cvap; E030013M08Rik; Gamma-CTF(50); Gamma-CTF(57); Gamma-CTF(59); Gamma-secretase C-terminal fragment 50; Gamma-secretase C-terminal fragment 57; Gamma-secretase C-terminal fragment 59; N-APP; P3(40); P3(42); peptidase nexin-II; PN2; PN-II; PreA4; protease nexin II; protease nexin-II; S-APP-alpha; S-APP-beta; Soluble APP-alpha; Soluble APP-beta; testicular tissue protein Li 2; ß APP42; ßAPP42
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 351
• Content And Storage: -20°C
• Form: Liquid

• Applications: Dot Blot, ELISA, Functional Assay, Immunohistochemistry, Radioimmune Assays (RIA)
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: P05067
• Gene Symbols: APP
• Immunogen: Synthetic peptide derived from amino acids 36-42 within the C-terminal region of human beta-Amyloid protein.
• Quantity: 25 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG