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Invitrogen™ beta Arrestin 1 Monoclonal Antibody (ZA005)
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Catalog No. 395000
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Catalog No. Quantity
39-500-0 100 μg
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Catalog No. 39-500-0 Supplier Invitrogen™ Supplier No. 395000
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Description

Mouse Monoclonal Antibody

beta Arrestin 1 Monoclonal Antibody for ELISA, ICC/IF, Western Blot

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
TRUSTED_SUSTAINABILITY

Specifications

Antigen beta Arrestin 1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone ZA005
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide; pH 7.4
Gene ARRB1
Gene Accession No. P29066, P49407, Q8BWG8
Gene Alias 1200006I17Rik; ARB1; ARR1; ARRB1; ARRB1 protein; arrdc1; arrestin; arrestin 2; arrestin beta 1; arrestin beta-1; arrestin, beta 1; arrestin-2; AW208571; BARRES; beta-arrestin; beta-arrestin1; beta-arrestin-1; G430100A01Rik; Non-visual arrestin-2
Gene Symbols ARRB1
Host Species Mouse
Immunogen Synthetic peptide derived from the C-terminal region of human beta-arrestin 1.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 109689, 25387, 408
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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