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beta Arrestin 1 Rabbit anti-Human, Mouse, Polyclonal, Proteintech Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Proteintech Group IncSupplier Diversity Partner 153611AP

Catalog No. 50-173-0178


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Description

Description

Beta Arrestin 1 is a member of a family of proteins widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling and mediates agonist-dependent desensitization and internalization of Gprotein-coupled receptors (GPCRs, e.g., beta 2-adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G-protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
Specifications

Specifications

beta Arrestin 1
0.13 mg/mL
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
P49407, Q8BWG8
ARB1, ARR1, ARRB1, Arrestin beta 1, arrestin, beta 1, Beta arrestin 1, beta-Arrestin-1
Rabbit
IgG
150 μL
-20°C
Primary
109689, 408
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Unconjugated
ARRB1
Liquid
ARRB1
beta Arrestin 1 Fusion Protein Ag7608
Antigen Affinity Chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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