beta-Catenin Rabbit anti-Human, Mouse, Rat, Zebrafish, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-1649	150 μL

Catalog No. 50-173-1649 Supplier Proteintech Group Inc Supplier No. 175651AP150UL

Description

Rabbit Polyclonal Antibody

Beta-catenin, an adherens junction (AJ) protein, was originally identified as a component of cell-cell adhesion structures. AJs are necessary for the creation and maintece of epithelial cell layers by regulating cell growth and adhesion between cells. Beta-catenin interacts with the cytoplasmic domain of E-cadherin and links E-cadherin to alpha-catenin, which in turn mediates anchorage of the E-cadherin complex to the cortical actin cytoskeleton. Studies show that Beta-catenin also binds to another cytoskeletal complex containing the adenomatous polyposis coli protein and microtubules, and interacts with several signaling pathways that include tyrosine kinases, phosphatases and Wnt/Wingless. The interplay between beta-catenin, cytoskeletal complexes and signaling pathways may regulate morphogenesis. Beta-catenin is expressed in several hair follicle cell types, basal and peripheral matrix cells, and cells of the outer and inner root sheats. A pathological role of beta-catenin has been identified in pilomatrixoma (PTR), medulloblastoma (MDB), colorectal cancer (CRC), ovarian cancer, and tumor development. In the nucleus, beta-catenin serves to co activate a family of Lef/Tcf transcription factors that stimulate transcription of target genes including those encoding cyclin D and c-myc that promote cell proliferation.

Specifications

• Antigen: beta-Catenin
• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: CTNNB1
• Gene Accession No.: P35222, Q02248, Q9WU82
• Gene Alias: b cat, Beta catenin, beta-Catenin, Catenin beta 1, CTNNB, CTNNB1, PRO2286
• Gene Symbols: Ctnnb1
• Host Species: Rabbit
• Immunogen: beta-Catenin Fusion Protein Ag11763
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12387, 1499, 30265, 84353
• Target Species: Human, Mouse, Rat, Zebrafish
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG