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Invitrogen™ BFAR Polyclonal Antibody
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Catalog No. PIPA596998
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100 μL
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PIPA596998 100 μL
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Catalog No. PIPA596998 Supplier Invitrogen™ Supplier No. PA596998
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MEEPQKSYVN TMDLERDEPL KSTGPQISVS EFSCHCCYDI LVNPTTLNCG HSFCRHCLAL WWASSKKTEC PECREKWEGF PKVSILLRDA IEKLFPDAIR LRFEDIQQNN DIVQSLAAFQ KYGNDQIPLA PNTGRANQQM; Positive Samples: HepG2, SKOV3, A-549, SH-SY5Y, SW480, Mouse brain, Mouse heart, Mouse liver, Rat heart; Cellular Location: Endoplasmic reticulum membrane, Multi-pass membrane protein.

The bifunctional apoptosis inhibitor (BFAR) is scaffold protein that integrates signaling components of the cells apoptosis-regulatory machinery. BFAR is a multidomain protein capable of inhibiting apoptosis induced by TNF-family death receptors ('extrinsic pathway') as well as mitochondria-dependent apoptosis ('intrinsic pathway'). Interaction of BFAR with Bcl-2 or Bcl-XL via a SAM domain may contribute to the anti-apoptotic properties of BFAR. In addition, BFAR contains a DED-like domain that is capable of suppressing apoptosis mediated at the receptor level. BFAR is also thought to be involved in the regulation of neuronal survival.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BFAR
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.28 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene BFAR
Gene Accession No. Q5PQN2, Q8R079, Q9NZS9
Gene Alias 3010001A07Rik; AI666707; AW107665; BAR; Bfar; bifunctional apoptosis inhibitor; bifunctional apoptosis regulator; RING finger protein 47; RNF47
Gene Symbols BFAR
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human BFAR (NP_0576451).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 304709, 51283, 67118
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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