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BHC110/LSD1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501557124
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50-155-7124 100 μL
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Catalog No. 50-155-7124 Supplier Bethyl Laboratories, Inc Supplier No. A300216A
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Mouse

LSD1 is a histone demethylase that specifically demethylates ′Lys-4′ of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. LSD1 contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. LSD1 demethylates both mono- and tri-methylted ′Lys-4′ of histone H3. This protein may play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3 ′Lys-4′ on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. It may also demethylate ′Lys-9′ of histone H3, a specific tag for epigenetic transcriptional repression, thereby leading to derepression of androgen receptor target genes. Mutations affecting this gene can result in cleft palate, psychomotor retardation, and distintive facial features.

Specifications

Antigen BHC110/LSD1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene KDM1A
Gene Accession No. O60341
Gene Alias AOF2, LSD1
Gene Symbols KDM1A
Host Species Rabbit
Immunogen Between 825 and C-term
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23028
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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