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Invitrogen™ BHLHE41 Recombinant Rabbit Monoclonal Antibody (1H18L6)

Catalog No. 702917
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70-291-7 100 μg
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Catalog No. 70-291-7 Supplier Invitrogen™ Supplier No. 702917
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Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Pig, Cat. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

The BHLHE41 gene encodes a basic helix-loop-helix (bHLH) transcription factor located at the 12p12.1 susceptibility locus. It functions primarily as a nuclear transcriptional repressor, homodimerizing or heterodimerizing with various partners to regulate gene expression. BHLHE41 expression is highly tissue-specific and responsive to environmental cues. Genetic studies have highlighted its role in increasing xenograft tumor growth and its involvement in short sleep phenotypes. A notable mutation in BHLHE41 leads to a phenotype requiring only six hours of sleep, demonstrating its influence on sleep patterns. Moreover, BHLHE41 has been associated with osteoclast differentiation processes, indicating its involvement in cellular development. Its interaction with TFEB target genes suggests a protective role against certain types of cell death, emphasizing its complex role in cellular physiology.
TRUSTED_SUSTAINABILITY

Specifications

Antigen BHLHE41
Applications Western Blot
Classification Recombinant Monoclonal
Clone 1H18L6
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.2-7.4
Gene Bhlhe41
Gene Accession No. Q9C0J9
Gene Alias 2-Dec; 6430520M22Rik; basic helix-loop-helix domain containing, class B, 3; basic helix-loop-helix domain containing, class B3; basic helix-loop-helix family member e41; basic helix-loop-helix family, member e41; bHLH transcriptional factor Dec2; Bhlhb2l; Bhlhb3; bHLHe41; Class B basic helix-loop-helix protein 3; class E basic helix-loop-helix protein 41; Dec2; differentially expressed in chondrocytes protein 2; Enhancer-of-split and hairy-related protein 1; hDEC2; mDEC2; SHARP1; SHARP-1
Gene Symbols Bhlhe41
Host Species Rabbit
Immunogen Protein corresponding to human BHLH3 [aa246-aa482].
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79365
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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