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Invitrogen™ Bi-1 Monoclonal Antibody (20F430)
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Catalog No. 01676467
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100 μg
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Catalog No. Quantity
01-676-467 100 μg
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Catalog No. 01-676-467 Supplier Invitrogen™ Supplier No. MA141108
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Description

Mouse Monoclonal Antibody

Epitope mapping indicates that the antibody recognizes an epitope in the N-terminal region of Bi-1.

BI-1 (Bax Inhibitor 1) is in anti-apoptotic protein that has been linked to protection from apoptosis induced endoplasmic reticulum (ER) stress (reviewed in Bailley-Maitre et al, 2007). BI-1 contains several transmembrane domains, localizes to ER membranes, and has cytoprotective functions that are conserved in both animals and plants. BI-1 suppresses apoptosis induced by ectopic expression of the proapoptotic protein Bax as well as other types of stimuli. Cells from BI-1 knockout (KO) mice are hypersensitivite to apoptosis induced by ER stress-causing chemical agents (thapsigargin, tunicamycin, and brefeldin A) or by ischemia-reperfusion (IR) injury. Conversely, overexpression of BI-1 protects against apoptosis induced by ER stress and IR. The mechanism by which BI-1 protects cells from ER-stress induced apoptosis remains to be fully elucidated, itis thought to involve regulation of Ca2+ handling by the ER.
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Specifications

Antigen Bi-1
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone 20F430
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% gelatin and 0.05% sodium azide
Gene TMBIM6
Gene Accession No. P55061, P55062, Q9D2C7
Gene Alias 5031406P05Rik; Ab1-011; Ac1-149; Bax inhibitor 1; Bax inhibitor-1; BAXI1; Bi1; BI-1; Cc1-27; Tegt; testis enhanced gene transcript; testis-enhanced gene transcript protein; Tmbim6; transmembrane BAX inhibitor motif containing 6; transmembrane BAX inhibitor motif-containing protein 6
Gene Symbols TMBIM6
Host Species Mouse
Immunogen A synthetic peptide made to the N-terminal portion of the human Bax inhibitor 1 protein (between amino acids 1-40).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 110213, 24822, 7009
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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