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Tocris Bioscience™ BI 4394
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Quantity:
10 mg
50 mg
Description
BI 4394 is a highly potent and selective MMP-13 inhibitor (IC50 = 1 nM). BI 4394 inhibits the degradation of isolated bovine nasal cartilage explants (IC50 = 31 nM). It shows high selectivity (>1000 fold) for MMP-13 over other MMPs. In vivo, BI 4394 decreases the mean arthritic score vs control in a murine model of rheumatoid arthritis, when administered at a dose of 100 mg/kg over a 14-day period. BI 4394 is orally bioavailable.
Specifications
Specifications
Chemical Name or Material | 2-Ethyl 5-[3-[[[(4-carboxyphenyl)methyl]amino]carbonyl]-1-methyl-1H-pyrazol-5-yl]-1H-indole-2-carboxylate |
CAS | 1222173-37-6 |
Quantity | 50 mg |
Target | Synthetic Metalloprotease Inhibitors |
Molecular Formula | C24H22N4O5 |
Purity | 0.98 |
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