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Apexbio Technology LLC BI-D1870 501437-28-1 5mg
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Supplier:  Apexbio Technology LLC B22275

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BI-D1870 (CAS 501437-28-1) is a cell-permeable small molecule inhibitor that selectively targets the p90 ribosomal S6 kinase (RSK) family comprising RSK1 RSK2 RSK3 and RSK4 It functions as an ATP-competitive inhibitor exhibiting IC50 values of 31 nM 24 nM 18 nM and 15 nM against RSK1 RSK2 RSK3 and RSK4 respectively BI-D1870 demonstrates over 500-fold greater selectivity for RSK isoforms compared to other AGC kinases In cellular assays such as with Rat-2 cells it has been shown to induce phosphorylation of ERK1/ERK2 and subsequent CREB phosphorylation BI-D1870 is widely utilized for investigating RSK-mediated signal transduction and downstream cellular processes in biomedical research

Catalog No. 50-224-0139


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