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Apexbio Technology LLC (-)-Bicuculline methiodide(Synonyms: (-)-Bicuculline methiodide, Bicuculline methiodide), 50mg, CAS: 40709-69-1.
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Supplier:  Apexbio Technology LLC B708150

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(-)-Bicuculline methiodide (CAS 40709-69-1) is an antagonist of the -aminobutyric acid-A (GABA A) receptor inhibiting GABA binding with an IC 50 of approximately 500 M GABA A receptors are ligand-gated chloride ion channels mediating inhibitory neurotransmission in the central nervous system In studies using chick cerebellar synaptic membranes this enantiomer exhibited lower activity relative to the ( )-enantiomer Additionally in C elegans (-)-bicuculline methiodide helped demonstrate pharmacological distinctions between UNC-49 GABA receptors and mammalian GABA A receptors This compound is employed widely in neuropharmacological research exploring GABA receptor function and regulation

Catalog No. 50-000-61264


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