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Apexbio Technology LLC E-4031 dihydrochloride 113559-13-0 5mg
Supplier: Apexbio Technology LLC B68625
E-4031 dihydrochloride (CAS 113559-13-0) is a methanesulfonanilide compound classified as a class III antiarrhythmic agent It selectively inhibits ether- -go-go-related gene (ERG) family potassium channels including hERG (Kv11 1) with an IC50 of 29 nM and demonstrates binding affinities of 99 116 and 193 nM for ERG1 ERG2 and ERG3 respectively By blocking these voltage-gated K channels E-4031 dihydrochloride extends cardiac action potential duration and modulates inwardly rectifying potassium currents in myocardial and gastrointestinal cells This molecule is widely used to study ERG channel physiology arrhythmogenesis and pharmacological rescue of mutant hERG in long QT syndrome type 2
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