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Invitrogen™ Bim Monoclonal Antibody (1C2C8)
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Catalog No. PIMA515763
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100 μg
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PIMA515763 100 μg
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Catalog No. PIMA515763 Supplier Invitrogen™ Supplier No. MA515763
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Description

Mouse Monoclonal Antibody

A suggested positive control is Bim recombinant protein.

BIM belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Bim
Applications Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 1C2C8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene BCL2L11
Gene Accession No. O43521, O54918
Gene Alias 1500006F24Rik; BAM; Bcl2 interacting mediator of cell death; bcl-2 interacting mediator of cell death; bcl-2 interacting protein Bim; BCL2 like 11; Bcl-2 like 11; Bcl-2 related apoptotic gene product BimL; bcl2-interacting mediator of cell death; BCL2L11; Bcl2-L-11; BCL2-like 11 (apoptosis facilitator); bcl-2-like protein 11; bcl-2-like protein 11-like; bcl-2-related ovarian death agonist; bcl-2-related ovarian death protein; BIM; Bim EL; Bim-A; BIM-alpha6; BIM-beta6; BIM-beta7; BIMEL; BimEL protein; BimL; BOD; OTTHUMP00000197013; OTTHUMP00000204247; Unknown (protein for MGC:134444)
Gene Symbols BCL2L11
Host Species Mouse
Immunogen Recombinant protein corresponding to amino acids 2 to 198 of human Bim.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10018, 12125
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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