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Abcam Bisindolylmaleimide XI Hydrochloride, PKC Inhibitor, Solid, 1 mg

Catalog No. 502706086
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50-270-6086 1 mg
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Catalog No. 50-270-6086 Supplier Abcam Supplier No. AB1437831MG
May include imposed supplier surcharges.
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Description

Selective, cell-permeable protein kinase C inhibitor with high potency for PKCα and PKCβI.

  • Molecular Weight: 489 Da
  • Purity: >98%
  • Form: Solid
  • Inhibitor Activity: Selective, cell-permeable PKC inhibitor; displays 10-fold greater selectivity for PKCα (IC50 = 9 nM) and 4-fold greater selectivity for PKCβI (IC50 = 28 nM) over Ca²+-independent PKCε (IC50 = 108 nM).
  • Additional Targets: Inhibits GRK2, GRK5, and GRK6 (IC50 values are 29, 3.6, and 16 μM, respectively).
  • Biological Effects: Enhances cardiac contractility and protection from heart failure; prevents T-cell activation and proliferation (IC50s ranging from 30-150 nM).
  • CAS Number: 151342-35-7

The product is subject to the following: Abcam Restricted Use Statement

Specifications

Target Molecule Protein Kinase C (PKC), GRK2, GRK5, GRK6
Shipping Condition Ambient
Alternate Part Number Ro 32-0432 hydrochloride
Buffer 100% Ro 32-0432 hydrochloride
Content And Storage Store at -20°C.
Form Solid
Formulation 100% Ro 32-0432 hydrochloride
Quantity 1 mg
For Use With (Application) Protein kinase C inhibition, T-cell activation inhibition, Cardiac contractility research, Chronic inflammatory response research
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