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Bleomycin sulfate PROMO

Catalog No. J60727MAF25
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Catalog No.
J60727MAF25 10 mg
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Catalog No. J60727MAF25 Supplier Thermo Scientific Chemicals Supplier No. J60727MAPR/DEL

Description

Bleomycin sulfate, CAS # 9041-93-4, is a glycopeptide compound with antibiotic activity isolated from Streptomyces verticillus. It also exhibits anticancer activity.

General Description

  • Bleomycin sulfate was initially isolated from Streptomyces verticillus. It is a glycopeptide compound with antibiotic activity
  • It has the ability to induce oxidative cleavage of the DNA backbone, leading to apoptosis
  • Bleomycin sulfate can form a complex with iron that reduces oxygen to superoxide and hydroxyl radicals. These reactive oxygen species can cause single- and double-stranded breaks in DNA as well as promote carbohydrate oxidation, lipid peroxidation, and alterations in prostaglandin synthesis and degradation

Application

  • It can be used to inhibit DNA metabolism and slow or stop cell growth. This property explains its anticancer activity
  • Bleomycin sulfate can also be used to degrade RNA as it is more selective to RNA than DNA
  • Local injections of bleomycin sulfate in mouse models can induce sclerotic skin mimicking scleroderma
  • In laboratory research, bleomycin is used to induce pulmonary fibrosis in mice
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 9041-93-4
Molecular Formula C55H85N17O25S4
Molecular Weight (g/mol) 1512.619 g/mol
MDL Number MFCD00070310
InChI Key WUIABRMSWOKTOF-UHFFFAOYSA-N
PubChem CID 131664136
IUPAC Name [2-[2-[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[[5-[[1-[2-[4-[4-(3-dimethylsulfoniopropylcarbamoyl)-1,3-thiazol-2-yl]-1,3-thiazol-2-yl]ethylamino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-hyd
SMILES CC1=C(N=C(N=C1 N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)CO)O)OC(=N)[O-])O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)O

Specifications

Type Bleomycin Sulfate
Physical Form Powder
Color White
Quantity 10 mg
Merck Index 14,1318
Solubility Information Soluble in Water or DMSO
Chemical Name or Material Bleomycin sulfate

Safety and Handling

Hazard Category H340-H351-H361d
Hazard Statement

GHS H Statement

  • H340-H351
  • May cause genetic defects.
  • Suspected of causing cancer.
Precautionary Statement P201-P202-P281-P308+P313-P501c
EINECSNumber 232-925-2
RTECSNumber EC5991990
TSCA No
storageNote1 2° to 8°C
Recommended Storage Keep Cold
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