Invitrogen™ Blood Group H Antigen Monoclonal Antibody (86-N)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA17673

Catalog No. 01-670-407

Description

MA1-7673 detects H1 and H2 human blood from human samples. MA1-7673 has been successfully used in agglutination applications. The MA1-7673 immunogen is a H human blood protein. Store at 4ºC short term, long term store at -80ºC.

The H antigen is a precursor to the ABO blood groupantigens, present in people of all common blood types. The Bombay phenotype (hh) does not express antigen H on red blood cells, and therefore this type will also lack A or B antigens, similar to the O blood group. However, unlike O group, the H antigen is absent, hence the individuals produce isoantibodies to antigen H as well as to both A and B antigens. If they receive blood from someone with O blood group, the anti-H antibodies will bind to the H antigen on the red blood cells of the donor blood and destroy the RBCs bycomplement-mediated lysis. Therefore, people with Bombay phenotype can receive blood only from otherhhdonors, although they can donate as though they were type O. Some individuals with the blood group A1 may also be able to produce anti-H antibodies due to the complete conversion of all the H antigen to A1 antigen. Production of the H antigen, or its deficiency in the Bombay phenotype, is controlled at the H locus on chromosome 19. The H locus contains threeexonsthat span more than 5kbof genomic DNA, and encodes thefucosyltransferasethat produces the H antigen on RBCs. The H antigen is a carbohydrate sequence withcarbohydrateslinked mainly to protein (with a minor fraction attached toceramidemoiety).

Specifications

• Antigen: Blood Group H Antigen
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: Antibody with 1.25 mM EDTA, 0.3M NaCl and 0.1% sodium azide; pH 7.2
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgM

• Applications: Agglutination
• Clone: 86-N
• Conjugate: Unconjugated
• Gene Alias: ABH; BG-H; BG-H1; group h
• Immunogen: H human blood protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: 4°C short term, -80°C long term
• Form: Liquid