Invitrogen™ BMAL1 Polyclonal Antibody

Catalog No.	Quantity
PA1523	200 μL

Catalog No. PA1523 Supplier Invitrogen™ Supplier No. PA1523

Description

Rabbit Polyclonal Antibody

PA1-523 detects BMAL1/aryl hydrocarbon nuclear translocator 3 (ARNT3) from hamster and mouse tissues as well as recombinant human BMAL1. PA1-523 has been sucessfully used in Western blot procedures. By Western blot, this antibody detects a 110 kDa protein which corresponds to the product of a hamster GST-BMAL1 fusion construct overexpressed in E. coli. This antibody detects a non-specific band in U87-MG cell lysates at ~105kDa and in NIH-3T3 cell lysates at ~135kDa. PA1-523 immunizing peptide corresponds to amino acid residues 582-594 from mouse BMAL1. This sequence is completely conserved between mouse, rat, guinea pig, and human BMAL1. PA1-523 immunizing peptide (Cat. # PEP-075) is available for use in neutralization and control experiments.

The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene.

Specifications

• Antigen: BMAL1
• Applications: Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
• Gene: Arntl
• Gene Accession No.: O00327, Q9EPW1, Q9WTL8
• Gene Alias: Arnt3; ARNTL; ARNT-like protein 1, brain and muscle; aryl hydrocarbon receptor nuclear translocator like; aryl hydrocarbon receptor nuclear translocator-like; aryl hydrocarbon receptor nuclear translocator-like protein 1; basic-helix-loop-helix-PAS orphan MOP3; basic-helix-loop-helix-PAS protein MOP3; bHLHe5; bHLH-PAS protein JAP3; BMAL1; Bmal1 protein; BMAL1b; bmal1b'; BMAL1c; Brain and muscle ARNT-like 1; brain and muscle Arnt-like protein 1; CG8727 PA; class E basic helix-loop-helix protein 5; cycle; JAP3; LOW QUALITY PROTEIN: aryl hydrocarbon receptor nuclear translocator-like protein 1; member of PAS protein 3; member of PAS superfamily 3; MGC47515; MOP3; PAS domain-containing protein 3; PASD3; testis tissue sperm-binding protein Li 50e; tic
• Gene Symbols: Arntl
• Host Species: Rabbit
• Immunogen: Synthetic Peptide: C D(582) M I D N D Q G S S S P S(594).
• Purification Method: Antigen affinity chromatography
• Quantity: 200 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100755141, 11865, 29657, 406
• Target Species: Human, Mouse, Rat, Hamster
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG