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Invitrogen™ BMP-2 Polyclonal Antibody
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Catalog No. PA131215
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100 μg
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PA131215 100 μg
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Catalog No. PA131215 Supplier Invitrogen™ Supplier No. PA131215
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Description

Rabbit Polyclonal Antibody

A band is detected around 45 kDa.

Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).
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Specifications

Antigen BMP-2
Applications Dot Blot, ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.73 mg/mL
Conjugate Unconjugated
Formulation Tris glycine with 0.5% BSA, 30% glycerol and 0.02% sodium azide; pH 7.4-7.9
Gene BMP2
Gene Accession No. P12643, P21274, P49001
Gene Alias 2610024H22Rik; AI467020; AL117858; AW546137; BB189135; BDA2; BMP; BMP2; BMP-2; BMP2A; BMP-2A; BMPRII; BMPR-II; Bone morphogenetic; Bone morphogenetic protein; Bone morphogenetic protein 2; bone morphogenetic protein 2 precursor (BMP-2) (BMP-2A); bone morphogenetic protein 2A; H-BMP-2; morphogen
Gene Symbols BMP2
Host Species Rabbit
Immunogen Synthetic peptide corresponding to Mouse BMP2 amino acid region 45-60 conjugated to Keyhole Limpet Haemocyanin (KLH).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12156, 29373, 650
Target Species Human, Mouse, Rat, Monkey, Baboon
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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