Invitrogen™ BMPR1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ 386000

Catalog No. 38-600-0

Description

BMPR1A Polyclonal Antibody for Western Blot, ICC/IF, IP

BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Specifications

• Antigen: BMPR1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BMPR1A
• Gene Alias: 10q23del; 1110037I22Rik; activin A receptor, type II-like kinase 3; activin receptor-like kinase 3; ACVRLK3; ALK3; ALK-3; AU045487; BMP type-1A receptor; BMP-2/BMP-4 receptor; Bmpr; Bmpr1a; BMPR-1A; BMPRIA; BMPR-IA; Bone morphogenetic protein 4 receptor; bone morphogenetic protein receptor type 1A; bone morphogenetic protein receptor type IA; bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type 1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12166, 657, 81507
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.4
• Gene Accession No.: P36894, P36895, Q78EA7
• Gene Symbols: BMPR1A
• Immunogen: Synthetic peptide derived from an internal region of the human BMPR-1A (bone morphogenetic protein receptor type 1A, Serine/threonine protein kinase receptor R5 (SKR5), activin receptor-like kinase-3 (ALK-3)), which differs from mouse and rat BMPR-1A by one nonconservative amino acid replacement.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG