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STEMCELL Technologies BMS 493, Size: 10 mg
Supplier: STEMCELL Technologies 73974
BMS 493 is an inverse agonist of the pan-retinoic acid receptors (RARs). RARs are ligand-dependent transcription factors that regulate gene networks that control cell growth, differentiation, survival, and death (Germain et al.). BMS 493 has been shown to increase nuclear receptor co-repressor (NCoR) interaction with RARs (Germain et al.; Rinkevich et al.).DIFFERENTIATION· Affects development of bronchial tubule formation in mice (Chazaud et al.).· Inhibits activation of immature dendritic cells (Geissmann et al.).CANCER RESEARCH · Inhibits differentiation of leukemic blasts (Kamashev et al.).
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