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Tecan Protein Fragment BoxB from HMGB1, human & mouse, LPS-free
Supplier: Tecan REHM052
BoxB from HMGB1, human & mouse, with tag, LPS-free - 100 ug . BoxB is one of the DNA binding domains of HMGB1 protein (HMG boxes). Structure-function analysis revealed that the cytokine activity of HMGB1 can be reproduced by recombinant BoxB. It recapitulates the cytokine activity of full length HMGB1 and efficiently activates macrophages to release tumor necrosis factor (TNF) and other proinflammatory cytokines. BoxB from HMGB1 is produced in E.coli from an expression plasmid coding for the mammalian sequence, which is totally identical in human and mouse, preceded by four amino acids (MARI) that have been added for the purpose of expression in bacteria, both of which have counterparts in other eukaryotic regulatory proteins. Distributed by IBL. Research Use Only.
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