Invitrogen™ BRE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA581287

Catalog No. PIPA581287

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human BRE/BRCC45.

BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

Specifications

• Antigen: BRE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: BABAM2
• Gene Alias: 6030405P19Rik; AI429776; B830038C02Rik; BABAM2; brain and reproductive organ-expressed (TNFRSF1A modulator); brain and reproductive organ-expressed protein; BRCA1/BRCA2-containing complex subunit 45; BRCA1/BRCA2-containing complex, subunit 4; BRCA1-A complex subunit BRE; BRCC4; BRCC45; BRE; bre {ECO:0000312; BRISC and BRCA1-A complex member 2; RGD:735111}
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 9577
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: Q9NXR7
• Gene Symbols: BABAM2
• Immunogen: A synthetic peptide corresponding to the C-terminus of the Human BRCC45.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov