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Apexbio Technology LLC Pemetrexed 150399-23-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A43905.1
Pemetrexed (CAS 150399-23-8) is a folate antagonist that targets multiple enzymes involved in the de novo synthesis of purine and pyrimidine nucleotides including thymidylate synthase (TS) dihydrofolate reductase (DHFR) glycinamide ribonucleotide formyltransferase (GARFT) and aminoimidazole carboxamide ribonucleotide formyltransferase (AICARFT) Structurally related to the antifolate compound lometrexol Pemetrexed disrupts nucleotide biosynthesis and subsequently inhibits DNA replication in proliferating cells It has demonstrated enzymatic inhibition across several pathways though exhibits limited cytotoxic activity in a range of tumor cell types such as non-small cell lung cancer mesothelioma breast colorectal cervical head and neck and bladder cancers This compound is widely used in preclinical studies of folate pathway inhibition and antimetabolite chemotherapy research
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