Invitrogen™ BSEP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578690

Catalog No. PIPA578690

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human HCCT tissue, rat liver tissue, mouse liver tissue. IHC: Mouse Liver tissue, Rat Liver tissue, Human Liver Cancer tissue.

ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.

Specifications

• Antigen: BSEP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ABCB11
• Gene Alias: ABC member 16, MDR/TAP subfamily; ABC16; Abcb11; ATP binding cassette subfamily B member 11; ATP-binding cassette sub-family B member 11; ATP-binding cassette, subfamily B (MDR/TAP), member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, sub-family B, member 11; bile salt export pump; BRIC2; Bsep; Lith1; PFIC2; PFIC-2; PGY4; progressive familial intrahepatic cholestasis 2; sister of P-glycoprotein; sister p-glycoprotein; Spgp
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27413, 83569, 8647
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.01mg sodium azide
• Gene Accession No.: O70127, O95342, Q9QY30
• Gene Symbols: ABCB11
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB11 (1175-1199aa KYGDNTKEIPMERVIAAAKQAQLHD).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov