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BTRC Mouse anti-Human, Clone: OTI1F3, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF502469

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. This protein is homologous to Xenopus bTrCP1, yeast Met30, Neurospora Scon2 and Drosophila Slimb proteins. It interacts with HIV-1 Vpu and connects CD4 to the proteolytic machinery. It also associates specifically with phosphorylated IkappaBalpha and beta-catenin destruction motifs, probably functioning in multiple transcriptional programs by activating the NF-kappaB pathway and inhibiting the beta-catenin pathway.Specifications
BTRC | |
Monoclonal | |
Unconjugated | |
BTRC | |
BETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, bTrCP, bTrCP1, betaTrCP | |
Mouse | |
Affinity Chromatography | |
RUO | |
8945 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI1F3 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
Q9Y297 | |
BTRC | |
Human fragment corresponding to amino acids 52-354 of human BTRC produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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