BubR1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-155-7506	100 μL

Catalog No. 50-155-7506 Supplier Bethyl Laboratories, Inc Supplier No. A300386A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Panda, Orangutan, Monkey and Gorilla

Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to maligt transformations. Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1. They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions. hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early. BUBR1 has been detected in human cancers. It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.

Specifications

• Antigen: BubR1
• Applications: Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: BUB1B
• Gene Accession No.: O60566, Q9Z1S0
• Gene Alias: BUB1B, Budding Uninhibited by Benzimidazoles 1 beta, hBUBR1, MAD3L
• Gene Symbols: BUB1B
• Host Species: Rabbit
• Immunogen: Between 350 and 400
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 12236, 171576, 701
• Target Species: Human, Mouse, Rat
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG