Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 502562312

AdipoGen Bumetanide
SDP

Supplier:  AdipoGen AGCR13543M250

Encompass_Preferred

Chemical. CAS 28395-03-1. Formula C17H20N2O5S. MW 364.4. Bumetanide is a loop diuretic that is clinically used to treat congestive heart failure. Bumetanide also exhibits anxiolytic, neuroprotective and anti-epileptic/anticonvulsant activities. Bumetanide induces hyperpolarization in kidney cells, increasing whole-cell conductance and intracellular Ca2 levels. Bumetanide acts by antagonizing Na/K/2Cl- symporter 1 NKCC1, K/Ca2 co-transporter 2 KCC2 and NKCC2, decreasing fluid secretion and Na/K transport. While NKCC1 is expressed both in the CNS and in systemic organs, NKCC2 is kidney-specific. Bumetanide is a potent and specific inhibitor of Na-K-2Cl cotransporter 1 NKCC1 IC50 = 0.68µM. It is selective for NKCC1 over NKCC2 IC50 = 4µM. It is also an agonist of G protein-coupled receptor 35 GPR35 EC50 = 10µM and can inhibit carbonic anhydrases IX and XII.

Catalog No. 50-256-2312


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Your feedback has been submitted: Thank you for helping us improve our website.