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c-Cbl Mouse anti-Human, Clone: 2F6D1, Proteintech
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Catalog No. 501736994 Shop All Proteintech Group Inc Products
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50-173-6994 150 μL
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Catalog No. 50-173-6994 Supplier Proteintech Group Inc Supplier No. 665761IG150UL
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Description

Mouse Monoclonal Antibody

Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.

Specifications

Antigen c-Cbl
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone 2F6D1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene CBL
Gene Accession No. P22681
Gene Alias C CBL, CBL, CBL2, c-Cbl, Proto oncogene c Cbl, RING finger protein 55, RNF55
Gene Symbols CBL
Host Species Mouse
Immunogen c-Cbl Fusion Protein Ag23033
Purification Method Protein G
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 867
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG1
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