Invitrogen™ C/EBP alpha Monoclonal Antibody (15C8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA1825

Catalog No. MA1825

Description

MA1-825 detects C/EBP alpha protein in human, mouse and rat samples. MA1-825 has successfully been used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 45 kDa protein representing C/EBP alpha in transfected hu293T cells. MA1-825 is specific to the amino terminal region of C/EBP alpha. The MA1-825 immunogen is a synthetic peptide corresponding to residues M(1) E S A D F Y E V E P R P P(14) of mouse C/EBP alpha. This peptide (Cat. # PEP-242) is available for use in neutralization and control experiments.

The C/EBP (CCAAT/enhancer binding protein) family of transcription factors--alpha, beta, delta, and epsilon)--are widely expressed proteins found in a variety of tissues. These domains contain an evolutionarily conserved five-amino acid motif (the regulatory domain motif RDM) that conforms to the consensus sequence (I/V/L) KXEP. One of the major roles of these transcription factors is that of metabolic regulation in liver and fat cells. Studies suggest that these transcription factors act in a cascade aiding in the development of the adipose cell. Three C/EBP beta isoforms (LAP*, LAP, and LIP) arise from different translation initiation and display different function in gene regulation. From a neurological standpoint, C/EBPs have been implicated in the mediation of nerve growth factor, altering synaptic plasticity, and mediation of inflammatory response in AD patients.

Specifications

• Antigen: C/EBP alpha
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1 mg/mL BSA and 0.05% sodium azide
• Gene Accession No.: P05554, P49715, P53566
• Gene Symbols: CEBPA
• Immunogen: Synthetic peptide corresponding to residues M(1) E S A D F Y E V E P R P P(14) of mouse C/EBP alpha.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Western Blot
• Clone: 15C8
• Conjugate: Unconjugated
• Gene: CEBPA
• Gene Alias: C EBP; C/EBP; c/EBP alpha; C/EBPa; C/ebpalpha; C/EBP-alpha; CAAT/enhancer-binding protein DNA-binding protein; CAAT/enhancer-binding protein, DNA-binding protein; CBF-A; CCAAT enhancer binding protein alpha; CCAAT/enhancer binding protein (C/EBP), alpha; CCAAT/enhancer binding protein alpha; CCAAT/enhancer binding protein, alpha; CCAAT/enhancer-binding protein alpha; Cebp; Cebpa; DBPCEP; OTTHUMP00000220269
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 1050, 12606, 24252
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid