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Invitrogen™ c-Fos Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA517489
Description
It is not recommended to aliquot this antibody. This antibody is not cross-reactive with other Fos proteins, including FosB, FRA1 and FRA2.
FBJ murine osteosarcoma viral oncogene homolog is commonly known as Cellular protooncogene Fos (c-Fos). It belongs to the fos transcription factor family and is encoded by the C-FOS gene located on chromosome 14. c-Fos heterodimerizes with c-Jun to form the Activator Protein -1 (AP-1) transcription factor which regulates transcription of several genes that play an important role in cellular signal transduction, cell proliferation and differentiation. c-Fos has been shown to be phosphorylated by various stimuli including growth factors and insulin at atleast seven different sites. The best known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK which regulates localization of c-Fos to the nucleus and is thus important for c-Fos induced transcriptional activity.
Specifications
c-Fos | |
Polyclonal | |
Unconjugated | |
FOS | |
activator protein 1; AP-1; cellular oncogene c-fos; cellular oncogene fos; cFos; C-FOS; c-fos oncogene; c-fos protooncogene protein; D12Rfj1; FBJ murine osteosarcoma viral (v-fos) oncogene homolog (oncogene FOS); FBJ murine osteosarcoma viral oncogene homolog; FBJ murine osteosarcoma viral oncogene homolog B; FBJ osteosarcoma oncogene; FBJ osteosarcoma oncogene B; FBJ osteosarcoma viral oncogene isoform deltaFosb-2; FOS; Fos proto-oncogene, AP-1 trancription factor subunit; Fos proto-oncogene, AP-1 transcription factor subunit; Fosb; FosB proto-oncogene, AP-1 transcription factor subunit; fra-2; G0/G1 switch regulatory protein 7; G0S7; I79_009428; p55; protein fosB; proto-oncogene cFOS; proto-oncogene c-Fos; proto-oncogene protein c-fos; v-fos FBJ murine osteosarcoma viral oncogene homolog | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
14281, 2353, 314322 | |
-20°C | |
Liquid |
Western Blot | |
107 μg/mL | |
0.01M HEPES with 100μg/mL BSA, 50% glycerol, 0.15M NaCl and no preservative; pH 7.5 | |
P01100, P01101, P12841 | |
FOS | |
Synthetic peptide corresponding to amino acids near the carboxy-terminus of human c-Fos protein. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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