Invitrogen™ C17orf96 Recombinant Rabbit Monoclonal Antibody (5H7L8)

Catalog No.	Quantity
70-305-2	100 μg

Catalog No. 70-305-2 Supplier Invitrogen™ Supplier No. 703052

Description

Rabbit Recombinant Monoclonal Antibody

This antibody is predicted to react with Monkey, Pig, Cat, Dog. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Elongin BC and Polycomb repressive complex 2-associated protein (EPOP) also know as C17ORF96 is a scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex. It is required to fine tune the transcriptional status of polycomb group (PcG) target genes in embryonic stem cells (ESCs). C17ORF96 also plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression of PcG target genes. It acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. C17ORF96 also has interacts with USP7 and promotes deubiquitination of H2B at promoter sites.

Specifications

• Antigen: C17orf96
• Applications: ChIP Assay, Western Blot, Immunocytochemistry, Western Blot
• Classification: Recombinant Monoclonal
• Clone: 5H7L8
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.09% sodium azide; pH 7.2-7.4
• Gene: EPOP
• Gene Accession No.: A6NHQ4, Q7TNS8
• Gene Alias: AA409164; AI413509; AW539173; C17orf96; C9H17orf96; chromosome 17 open reading frame 96; CUNH17orf96; E13; E130012A19Rik; elongin BC and polycomb repressive complex 2 associated protein; elongin BC and Polycomb repressive complex 2-associated protein; Embryonic stem cell-specific PRC2 subunit p48; EPOP; ES cell-specific PRC2 subunit p48; esPRC2p48; hypothetical protein LOC691153; LOC691153; proline rich 28; Proline-rich protein 28; PRR28; RIKEN cDNA E130012A19 gene; uncharacterized protein C17orf96; uncharacterized protein C17orf96 homolog; Uncharacterized protein ENSP00000317905
• Gene Symbols: EPOP
• Host Species: Rabbit
• Immunogen: Peptides corresponding to human C17orf96 [aa130-aa148, aa360-aa379].
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 100170841, 103551
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov