C19orf62 Rabbit anti-Human, Polyclonal, Proteintech

Catalog No.	Quantity
50-173-5786	150 μL

Catalog No. 50-173-5786 Supplier Proteintech Group Inc Supplier No. 279261AP150UL

Description

Rabbit Polyclonal Antibody

HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes ′Lys-63′-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes ′Lys-63′-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves ′Lys-63′-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the ′Lys-63′-linked deubiquitinase activity mediated by BRCC3/BRCC36.

Specifications

• Antigen: C19orf62
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.33 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene: BABAM1
• Gene Accession No.: Q9NWV8
• Gene Alias: BABAM1, C19orf62, HSPC142, MERIT40, NBA1
• Gene Symbols: BABAM1
• Host Species: Rabbit
• Immunogen: C19orf62 Fusion Protein Ag27459
• Purification Method: Antigen Affinity Chromatography
• Quantity: 150 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 29086
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG