C2 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Supplier:  Proteintech Group Inc 271751AP150UL

Catalog No. 50-173-5588

Description

Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. ActivatedC1 cleaves C2 into C2a and C2b. The serine proteinase C2a thencombines with complement factor 4b to create the C3 or C5convertase. Deficiency of C2 has been reported to associated withcertain autoimmune diseases and SNPs in this gene have beenassociated with altered susceptibility to age-related maculardegeneration. This gene localizes within the class III region ofthe MHC on the short arm of chromosome 6. Alternative splicingresults in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publicationsbut their full-length sequence has not been determined.

Specifications

• Antigen: C2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: C2
• Gene Alias: C2, C3/C5 convertase, CO2, Complement C2, complement component 2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 717
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.23 mg/mL
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Accession No.: P06681
• Gene Symbols: C2
• Immunogen: C2 Fusion Protein Ag25690
• Quantity: 150 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG