C2 Rabbit anti-Human, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-5588	Proteintech Group Inc 271751AP150UL	150 μL

Description

Component C2 is a serum glycoprotein that functions aspart of the classical pathway of the complement system. ActivatedC1 cleaves C2 into C2a and C2b. The serine proteinase C2a thencombines with complement factor 4b to create the C3 or C5convertase. Deficiency of C2 has been reported to associated withcertain autoimmune diseases and SNPs in this gene have beenassociated with altered susceptibility to age-related maculardegeneration. This gene localizes within the class III region ofthe MHC on the short arm of chromosome 6. Alternative splicingresults in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publicationsbut their full-length sequence has not been determined.

Specifications

• Antigen: C2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human
• Gene Accession No.: P06681
• Gene ID (Entrez): 717
• Immunogen: C2 Fusion Protein Ag25690
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: C2

• Concentration: 0.23 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: C2, C3/C5 convertase, CO2, Complement C2, complement component 2
• Gene Symbols: C2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody