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CACNA1S Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501733811 Shop All Proteintech Group Inc Products
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50-173-3811 150 μL
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Catalog No. 50-173-3811 Supplier Proteintech Group Inc Supplier No. 222791AP150UL
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Description

Rabbit Polyclonal Antibody

The antibody is specific to CACNA1S.

Voltage-sensitive calcium channels mediate the entry of calcium into many types of excitable cells and thus play a key role in neurotransmitter release and excitation-contraction (E-C) coupling. The 1,4-dihydropyridines (DHPs) are synthetic organic compounds which can be used to identify the L-type calcium channels that are found in all types of vertebrate muscle, neuronal and neuroendocrine cells. The DHP receptor is part of the L-type calcium channel complex and is thought to be the voltage sensor in E-C coupling. The purified DHP receptor isolated from triads is composed of at least four subunits. The alpha-1 subunit contains the binding site for the DHPs and shows high sequence homology to the voltage gated sodium channel. The alpha-2 subunit is a large glycoprotein associated with the DHP receptor which was first described in skeletal muscle and is also found in high concentrations in other excitable tissues such as cardiac muscle and brain and in low concentrations in most other tissues studied. The other two subunits that co-purify with the DHP receptor are termed beta and gamma.

Specifications

Antigen CACNA1S
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.19 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CACNA1S
Gene Accession No. Q13698
Gene Alias CACH1, CACN1, CACNA1S, CACNL1A3, Cav1.1, CCHL1A3, HOKPP, hypoPP, MHS5
Gene Symbols CACNA1S
Host Species Rabbit
Immunogen Peptide
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 779
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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