Invitrogen™ CACNA2D1 Monoclonal Antibody (20A)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA3921

Catalog No. MA3921

Description

MA3-921 detects 1,4-dihydropyridine (DHP) receptor alpha-2 subunit from human, rat, mouse, guinea pig and rabbit skeletal and cardiac muscle. MA3-921 has been successfully used in Western blot, immunocytochemistry, immunofluorescence, and immunohistochemistry procedures. By Western blot, this antibody detects a 220 kDa protein under non-reducing and a 143 kDa protein under reducing conditions representing DHP from rabbit skeletal muscle membrane preparations. Immunohistochemical staining of DHP in rabbit skeletal muscle with MA3-921 results in double rows of discrete punctate staining representing pairs of triads on the opposing sides of the Z-lines. The MA3-921 antigen is purified rabbit DHP receptor.

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Specifications

• Antigen: CACNA2D1
• Classification: Monoclonal
• Concentration: Conc. Not Determined
• Formulation: Ascites with 0.05% sodium azide
• Gene Accession No.: O08532, P13806, P54289, P54290
• Gene Symbols: Cacna2d1
• Immunogen: Purified rabbit dihydropyridine receptor.
• Regulatory Status: RUO
• Gene ID (Entrez): 100009105, 100728887, 12293, 25399, 781
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 20A
• Conjugate: Unconjugated
• Gene: Cacna2d1
• Gene Alias: Ca(v)alpha2delta1; Cacna2; Cacna2d1; CACNL2A; Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type); calcium channel, L type, alpha 2 polypeptide; calcium channel, voltage-dependent, alpha 2/delta subunit 1; calcium channel, voltage-dependent, alpha2/delta subunit 1; calcium voltage-gated channel auxiliary subunit alpha2delta 1; CCHL2A; CCHLA2; DHP; DHSCCA; dihydropryridine-sensitive calcium channel alpha-2 subunit; dihydropyridine-sensitive calcium channel alpha 2; dihydropyridine-sensitive L-type, calcium channel alpha-2/delta subunit; H_DJ0560O14.1; LINC01112; lncRNA-N3; MHS3; unknown protein; voltage-dependent calcium channel alpha-2 delta subunit precursor; Voltage-dependent calcium channel subunit alpha-2/delta-1; Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1; Voltage-gated calcium channel subunit alpha-2/delta-1; WUGSC:H_DJ0560O14.1
• Host Species: Mouse
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat, Rabbit, Guinea Pig
• Product Type: Antibody
• Isotype: IgG2a