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Invitrogen™ CADM1 Polyclonal Antibody
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Catalog No. PIPA578905
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100 μg
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Catalog No. Quantity
PIPA578905 100 μg
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Catalog No. PIPA578905 Supplier Invitrogen™ Supplier No. PA578905
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Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: human hepatocellular carcinoma tumor tissue (HCCT), human hepatocellular carcinoma paracancerous tissue (HCCP), human HepG2 whole cell, rat liver tissue, mouse brain tissue, mouse liver tissue. Flow: A549 cell.

Mediates homophilic cell-cell adhesion in a Ca (2+)-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca (2+)-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CADM1
Applications Flow Cytometry, Western Blot
Classification Polyclonal
Concentration 500 μg/mL
Conjugate Unconjugated
Formulation PBS with 4mg trehalose and 0.05mg sodium azide
Gene CADM1
Gene Accession No. Q6AYP5, Q8R5M8, Q9BY67
Gene Alias 2900073G06Rik; 3100001I08Rik; AI987920; Bl2; cadm1; Cell adhesion molecule 1; cell adhesion molecule 1 transcript variant 8abc; Igsf4; Igsf4a; Immunoglobulin superfamily member 4; immunoglobulin superfamily member 4A; immunoglobulin superfamily, member 4; immunoglobulin superfamily, member 4A; immunoglobulin superfamily, member 4D variant 1; immunoglobulin superfamily, member 4D variant 2; immunosuperfamily protein Bl2; Necl2; NECL-2; nectin-like 2; nectin-like protein 2; RA175; RA175A; RA175B; RA175C; RA175N; secretory isoform of TSLC1; sgigsf; Spermatogenic immunoglobulin superfamily; ST17; sTSLC-1; Synaptic cell adhesion molecule; SynCAM; SynCam1; truncated CADM1 protein; TSLC1; TSLC-1; TSLC1/Nectin-like 2/IGSF4; tumor suppressor in lung cancer 1; Tumor suppressor in lung cancer 1 homolog
Gene Symbols CADM1
Host Species Rabbit
Immunogen E.coli-derived human SynCAM recombinant protein (Position: Q45-P340).
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23705, 363058, 54725
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Lyophilized
Isotype IgG
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