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MilliporeSigma™ Calbiochem™ G-Protein βγ Binding Peptide, mSIRK

Catalog No. 3718185MG Shop All MilliporeSigma Products
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37-181-85MG 5 mg
37-181-81MG 1 mg
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Catalog No. 37-181-85MG Supplier MilliporeSigma™ Supplier No. 3718185MG
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Description

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange.

A cell-permeable, N-myristoylated G-protein βγ selective binding peptide that disrupts the interaction between α and βγ subunits and promotes the α subunit dissociation without stimulating nucleotide exchange. Shown to cause a rapid activation of ERK1/2 (EC50 ∽ 2.5 - 5μM) in rat arterial smooth muscle and Rat2 cells. Also promotes the phosphorylation of JNK and p38 MAP kinase, phospholipase C and causes Ca2+ release from internal stores. Negative control is also available (Cat. No. 371820).
TRUSTED_SUSTAINABILITY

Specifications

Formulation Supplied as a trifluoroacetate salt.
Target Proteins N-myristoylated G-protein βγ selective binding
Molecular Formula C93H150N20O25
Formula Weight 1948.3g/mol
Solubility DMSO
Content And Storage Hygroscopic
Form Lyophilized
Quantity 5 mg
Purity 95% by HPLC
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