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MilliporeSigma™ Calbiochem™ AhR Antagonist III, GNF351

AhR Antagonist III, GNF351, is a cell-permeable, high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC50 = 62nM in mouse liver cytosol expressing humanized AhR).

Manufacturer:  MilliporeSigma™ 18270710MG

Catalog No. 18-270-710MG


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Description

Description

A cell-permeable purine compound that acts as a high-affinity aryl hydrocarbon receptor (AhR) antagonist (IC50 = 62nM in mouse liver cytosol expressing humanized AhR) and lacks any agonist activity even at higher doses. Reportedly binds with high affinity to the ligand-binding pocket of AhR and blocks the binding of an array of exogenous and endogenous ligands. Shown to non-covalently interact with Ser317, His291, and Ser365 in human and with Ser311, His285, and Ser359 in mouse AhR. Represses AhR transcriptional activity via the dioxin response element (DRE)-dependent and independent mediated responses in human and mouse cells (IC50 = 8.5nM in HepG2 40/6 cells).
Specifications

Specifications

98% by HPLC
Protect from Light
C24H25N7
DMSO
Off-white solid
10mg
411.5g/mol
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